ncRNA name | hsa-miR-16 |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal endothelial cells (HRECs) |
Methods | transfection, qRT-PCR, Western blot, ELISA |
Expression pattern | down-regulated |
Functional description | miR-15b and miR-16 play a role in the inhibition of insulin resistance via reduced TNFα and SOCS3 signaling and increased IGFBP-3 levels, resulting in REC protection from hyperglycemia-induced apoptosis. |
PubMed ID | 25888955 |
Year | 2015 |
Title | miR-15b/16 protects primary human retinal microvascular endothelial cells against hyperglycemia-induced increases in tumor necrosis factor alpha and suppressor of cytokine signaling 3. |
Drug-related ncRNA | NO |
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